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With hundreds of identified districts, Baltimore has been dubbed a "city of neighborhoods".
Famous residents have included writers Edgar Allan Poe, Edith Hamilton, Frederick Douglass, and H. Mencken; jazz musician James "Eubie" Blake; singer Billie Holiday; actor and filmmaker John Waters; and baseball player Babe Ruth.
On February 7, 1904, the Great Baltimore Fire destroyed over 1,500 buildings in 30 hours, leaving more than 70 blocks of the downtown area burned to the ground.
European colonization of Maryland began with the arrival of an English ship at St. Europeans began to settle the area further north, beginning to populate the area of Baltimore County, The colonial General Assembly of Maryland created the Port of Baltimore at old Whetstone Point (now Locust Point) in 1706 for the tobacco trade.
These industries benefited from war but successfully shifted into infrastructure development during peacetime.
Soon after the city created the world's first dental college, the Baltimore College of Dental Surgery, in 1840, and shared in the world's first telegraph line, between Baltimore and Washington DC in 1844.
In the War of 1812, Francis Scott Key wrote The Star-Spangled Banner, which later became the American national anthem, in Baltimore.
and is home to some of the earliest National Register Historic Districts in the nation, including Fell's Point, Federal Hill, and Mount Vernon, which were added to the National Register between 1969–1971. The city has 66 National Register Historic Districts and 33 local historic districts. The Baltimore area had been inhabited by Native Americans since at least the 10th millennium BC, when Paleo-Indians first settled in the region.